Thalassemia is the most common single gene disorder in humans. It is estimated that about 300,000 babies are born every year with major hemoglobinopathies around the world. In Thalassemia, the life span of the red blood cells significantly reduces because of ineffective hemoglobin synthesis. Children affected by this disorder become transfusion-dependent for the rest of their lives. It is recommended that children with sickle cell anemia, hemolytic anemia and bone marrow failure should undergo regular blood transfusion to maintain their hemoglobin levels.